Shadow of the Ninja - Nintendo NES

Set in the year 2029, the evil dictator Emperor Garuda has taken over the United States of America, building a stronghold in the middle of the nation's "largest city". To stop Garuda and avenge the innocent lives that were lost in his reign, two ninja masters from the Iga clan, Lord Hayate and Lady Kaede, are sent to infiltrate Garuda's impregnable stronghold and assassinate him